I-PGA ne-HA: Ukuthuthukiswa Kwe-Synergistic, Ithi Goodbye Ekunamatheleni, Okuswakamamayo kanye Ne-Antioxidant Duet

#Isingeniso

I-Sodium polyglutamate (PGA)iyi-polymer encibilika emanzini ekhiqizwa nguukuvutshelwa kwe-microbial.Isetshenziswa kabanzi kuukunakekelwa kwesikhumbaimikhiqizo kanyeizimonyongenxa yezakhiwo zayo ezinhle kakhulu zokuthambisa kanye nezakhiwo eziningi.Lesi sihloko sizokwethula umthombo, ukwakheka kwamakhemikhali, izici kanye nokusetshenziswa kwei-sodium polyglutamateemikhiqizweni yokunakekelwa kwesikhumba ngokuningiliziwe.

#Umthombo kanye nesakhiwo samakhemikhali

I-sodium polyglutamateyaqala ukutholwa ku-natto, ukudla kwendabuko kwaseJapane.Usilika we-viscous ngokwedlulele ku-natto yi-I-PGA.Le nto yenziwe i-polymerized isuka ku-glutamic acid yemvelo futhi eyonakalayo futhi ikhiqizwa ukuvutshelwa kwe-Bacillus subtilis.I-Bacillus subtilis iyisithako se-microbial esiphephile esiqashelwa umhlaba wonke (GRAS), esitholakala ngokwemvelo futhi siphephile emzimbeni womuntu.

Isakhiwo esiyisisekelo seI-PGAyakhiwe ngama-molecule angu-5000-10000 we-glutamic acid polymerized ngokusebenzisaγ- izibopho ze-amide.I-molecule iqukethe inani elikhulu lamaqembu e-polar afana namaqembu e-hydroxyl ne-carboxyl, angakha amabhondi e-hydrogen ngaphakathi naphakathi kwama-molecule, ngaleyo ndlela abophe inani elikhulu lamanzi futhi athuthukise ngokuphawulekayo umphumela wawo wokuswakama.

#Izici kanye Nomphumela

1. **Ukusebenza okuhle kakhulu kokuthambisa**: I-PGA ingakwazi ukumunca futhi ikhiye inani elikhulu lamanzi, ithuthukise kakhulu ukugeleza kwesikhumba.Lapho isetshenziswa ngei-sodium hyaluronate (HA), ingandisa isikhathi somswakama we-HA, inciphise ukunamathela kwayo, futhi yenze isikhumba sizizwe singokwemvelo futhi sibushelelezi.

2. **Umsebenzi we-Antioxidant**: I-PGA inomsebenzi we-antioxidant, ingasusa ama-radicals mahhala, futhi ivikele isikhumba ekulimaleni kwe-oxidative.Ucwaningo luye lwabonisa ukuthi i-PGA enesisindo samangqamuzana angu-1.4 wezigidi ze-Da yenza kangcono kancane kune-PGA enesisindo samangqamuzana angu-1 we-Da ekukhipheni ama-radicals mahhala e-DPPH.

3. **Khulisa okuqukethwe kwe-natural moisturizing factor (NMF) esikhumbeni**: I-PGA ingakhuthaza ukukhiqizwa kwe-NMF esikhumbeni, ithuthukise ikhono lemvelo lokuswakama lesikhumba, futhi ifinyelele umphumela wokondleka okujulile.

4. **Ukuba mhlophe nokulwa nokuguga**: I-PGA ingakwazi ukulawula ngobumnene umsebenzi we-tyrosinase, ibambezele ukwakheka kwamabala, futhi ngesikhathi esifanayo ithuthukise ukuzinza kwe-HA esikhumbeni, ikhulise okuqukethwe kwe-HA, futhi ifinyelele umphumela wokuba mhlophe nokulwa nokuguga.

#Isisindo samangqamuzana nokusetshenziswa kwayo

Ngokwesisindo samangqamuzana, i-PGA ingahlukaniswa ngezinhlobo ezintathu: isisindo samangqamuzana aphezulu, isisindo samangqamuzana aphakathi nesisindo esiphansi samangqamuzana, ngayinye enezici ezihlukahlukene kanye nezicelo:

- **I-PGA-HMW (isisindo samangqamuzana aphezulu, >700kDa)**: ukuthambisa okuhlala isikhathi eside, ukwakha ifilimu ethambisayo ebusweni besikhumba, kuthuthukisa kakhulu umphumela wokuthambisa.

- **I-PGA-LMW (isisindo semolekyuli esimaphakathi, 70-150kDa)**: ithambisa futhi ibe mhlophe, ithuthukise ukukhazimula kwesikhumba nokunwebeka.

- **I-PGA-Oligo (isisindo esiphansi samangqamuzana, <10kDa)**: ukondliwa okujulile, okufinyelela ngokuqondile ungqimba oluyisisekelo, ukukhuthaza ukukhiqizwa kwe-NMF nokumuncwa kwemisoco.

# Izicelo kanye neziphakamiso zokusebenzisa

I-PGA ilungele ukuthambisa, ukulwa nokuguga kanye nemikhiqizo emhlophe, ngokuhlushwa okunconyiwe kwe0.1% ukuya ku-1%.Ama-emulsifiers we-Anti-ionic kufanele asetshenziswe ngendlela engenzeka kufomula ukuze kuthuthukiswe umphumela we-PGA.

#Isiphetho

Njenge-biopolymer yemvelo, ephephile futhi ephumelelayo,i-sodium polyglutamate (PGA)ikhombisa amandla amakhulu okusebenza emikhiqizweni yokunakekelwa kwesikhumba nezimonyo.Izakhiwo zayo ezinhle kakhulu zokuthambisa, umsebenzi we-antioxidant kanye nezinzuzo eziningi empilweni yesikhumba kuyenza ibe isithako esibalulekile emikhiqizweni yesimanje yokunakekelwa kwesikhumba.Ngokujula kocwaningo kanye nokuthuthuka kobuchwepheshe bezicelo,I-PGAkulindeleke ukuthi ibambe iqhaza elibalulekile emikhakheni eminingi futhi ilethe ukuqamba okusha nokuthuthukiswa kobuchwepheshe bokunakekelwa kwesikhumba.